• Length:
    12 Weeks
  • Effort:
    3–6 hours per week
  • Price:

    FREE
    Add a Verified Certificate for $150 USD

  • Institution
  • Subject:
  • Level:
    Intermediate
  • Language:
    English
  • Video Transcript:
    English

Prerequisites

Undergraduate introductory biology (biochemistry and molecular biology);
Undergraduate introductory chemistry;
Undergraduate organic chemistry I (chemical structures and biological mechanisms)

About this course

Skip About this course
Do you want to prepare for medical school, study a STEM field, become a research scientist, or transition to a career in the booming biotechnology industry? Or maybe you just want to understand the chemical reactions that govern life itself. Join Professor Yaffe, an MIT professor and practicing surgeon, as he guides you through the science that inspires countless doctors, researchers, and students alike.

We developed 7.05x Biochemistry with an emphasis on:
  • Developing your scientific thinking skills including articulating hypotheses, performing thought experiments, interpreting data, and designing experiments.
  • Using data based on real scientific experiments and highlighting the scientific process.
  • Asserting that biology is an active field that changes daily through examples of MIT (and other current) research, not static information in a textbook.
  • Visualizing real molecular structures with PyMOL to better understand function and mechanism.
  • Appreciating the quantitative aspects of biochemistry and practicing this quantitation with MATLAB.
  • Translating topics in biochemistry to diseases and medicine.  
  • Conveying the authentic MIT firehose experience.
  • Implementing the science of learning in the course design.
We offer a thorough and robust means of certifying edX learners in their mastery of the MITx biochemistry content, through the MITx 7.05x Biochemistry Competency Exam. This challenging option is available only to those who register for the verified-certificate track, and successful completion of this exam is the majority of the assessment grade that counts toward a certificate. The Competency Exam will be open from January 21, 2020 to January 28, 2020.

What you'll learn

Skip What you'll learn
  • How to apply the scientific method to pursue research questions.
  • How to analyze protein purification schemes.
  • How scientists determine the structure of a protein.
  • How structure, allostery, and the Bohr effect influence hemoglobin function.
  • How to interpret graphs, plot behaviors, and calculate constants related to enzyme function.
  • How pumps, transporters, and channels differ to regulate molecule transfer across membranes.
  • How G proteins play a key role in signaling.
The course includes the following learning sequences:
  • Introduction to Biochemistry; pH and Buffers
  • Amino Acids and Proteins
  • Protein Purification
  • Protein Structure 
  • Protein Folding
  • Hemoglobin and Allostery
  • Hemoglobin and the Bohr Effect
  • Enzyme Chemistry
  • Enzyme as Catalysts
  • Enzyme Kinetics
  • Membranes, Channels, Transporters, and Pumps
  • Blood Clotting
  • Signal Transduction

Meet your instructors

Michael Yaffe
Director, MIT Center for Precision Cancer Medicine; David H. Koch Professor in Science; Professor of Biological Engineering
Massachusetts Institute of Technology
Mary Ellen Wiltrout
MITx Digital Learning Scientist, Department of Biology
Massachusetts Institute of Technology
Darcy Gordon
MITx Digital Learning Fellow, Department of Biology
Massachusetts Institute of Technology
Monika Avello
MITx Digital Learning Fellow, Department of Biology
Massachusetts Institute of Technology

Pursue a Verified Certificate to highlight the knowledge and skills you gain $150.00

View a PDF of a sample edX certificate
  • Official and Verified

    Receive an instructor-signed certificate with the institution's logo to verify your achievement and increase your job prospects

  • Easily Shareable

    Add the certificate to your CV or resume, or post it directly on LinkedIn

  • Proven Motivator

    Give yourself an additional incentive to complete the course

  • Support our Mission

    EdX, a non-profit, relies on verified certificates to help fund free education for everyone globally

Learner testimonials

In short, if you enjoy the opportunity to 'virtually' study at a very high level with some of the finest practitioners in their field, this is among the very best courses available to engage that passion.” – Class Central learner review

For 1.5 hours three times a week, hundreds of students fill 10-250 (one of the giant lecture halls) to watch Yaffe cover crazy amounts of information in very little time. By the end of every lecture, you probably have four pages of very colorful notes and 9 boards filled with pretty picture of molecules and processes.” – MIT student blogger

Who can take this course?

Unfortunately, learners from one or more of the following countries or regions will not be able to register for this course: Iran, Cuba and the Crimea region of Ukraine. While edX has sought licenses from the U.S. Office of Foreign Assets Control (OFAC) to offer our courses to learners in these countries and regions, the licenses we have received are not broad enough to allow us to offer this course in all locations. EdX truly regrets that U.S. sanctions prevent us from offering all of our courses to everyone, no matter where they live.