• Length:
    7 Weeks
  • Effort:
    4–8 hours per week
  • Price:

    FREE
    Add a Verified Certificate for $99 USD

  • Institution
  • Subject:
  • Level:
    Advanced
  • Language:
    English
  • Video Transcripts:
    English, 中文

Prerequisites

7.00x Introduction to Biology or similar (undergraduate biochemistry, molecular biology, and genetics) and 7.28.1x Molecular Biology or similar (advanced DNA replication and repair) 

About this course

Skip About this course

In Part 2 of this Molecular Biology course, you’ll explore transcription of DNA to RNA, a key part of the central dogma of biology and the first step of gene expression.

Did you know that transposable elements, the genetic information that can move from location to location, make up roughly 50 % of the human genome? Did you know that scientists have linked their movement into specific genes to the causes of certain diseases? You’ll also learn how these “jumping genes” work and how scientists study them in Molecular Biology: Transcription and Transposition.

Are you ready to go beyond the “what" of scientific information presented in textbooks and explore how scientists deduce the details of these molecular models?

Take a behind-the-scenes look at modern molecular genetics, from the classic experimental events that identified the proteins and elements involved in transcription and transposition to cutting-edge assays that apply the power of genome sequencing. We've designed the problems in this course to build your experimental design and data analysis skills.

Let’s explore the limits of our current knowledge about the transcription machinery and mechanisms of transposition. If you are up for the challenge, join us in 7.28.2x Molecular Biology: Transcription and Transposition.

 

What you'll learn

Skip What you'll learn
  • How to compare and contrast transcription in prokaryotes and eukaryotes
  • How to describe several mechanisms of transposition
  • How to analyze protein structures to infer functional information
  • How to design the best experiment to test a hypothesis
  • How to interpret data from transcription and transposition experiments
Week 1: Machinery and Promoters of Bacterial Transcription
 
Week 2: Bacterial Regulation of Bacterial Transcription
 
Week 3: Machinery and Promoters of Eukaryotic Transcription
 
Week 4: Regulation of Eukaryotic Transcription I
 
Week 5: Regulation of Eukaryotic Transcription II
 
Week 6: Transposition

Week 7: CRISPR

Meet your instructors

Stephen P. Bell
HHMI Investigator; Professor of Biology
MIT
Tania A. Baker
HHMI Investigator; Whitehead Professor of Biology
MIT
Mary Ellen Wiltrout
MITx Digital Learning Scientist, Department of Biology
Massachusetts Institute of Technology
Nathaniel Schafheimer
MITx Digital Learning Fellow, Department of Biology
MIT

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Frequently asked questions

Who can take this course?

Unfortunately, learners from one or more of the following countries or regions will not be able to register for this course: Iran, Cuba and the Crimea region of Ukraine.  While edX has sought licenses from the U.S. Office of Foreign Assets Control (OFAC) to offer our courses to learners in these countries and regions, the licenses we have received are not broad enough to allow us to offer this course in all locations.  EdX truly regrets that U.S. sanctions prevent us from offering all of our courses to everyone, no matter where they live.

Who can take this course?

Unfortunately, learners from one or more of the following countries or regions will not be able to register for this course: Iran, Cuba and the Crimea region of Ukraine. While edX has sought licenses from the U.S. Office of Foreign Assets Control (OFAC) to offer our courses to learners in these countries and regions, the licenses we have received are not broad enough to allow us to offer this course in all locations. EdX truly regrets that U.S. sanctions prevent us from offering all of our courses to everyone, no matter where they live.