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HarvardX: Introduction to Bioconductor

The structure, annotation, normalization, and interpretation of genome scale assays.

4 semanas
2–4 horas por semana
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Comienza el 28 mar
Termina el 27 nov

Sobre este curso

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We begin with an introduction to the relevant biology, explaining what we measure and why. Then we focus on the two main measurement technologies: next generation sequencing and microarrays. We then move on to describing how raw data and experimental information are imported into R and how we use Bioconductor classes to organize these data, whether generated locally, or harvested from public repositories or institutional archives. Genomic features are generally identified using intervals in genomic coordinates, and highly efficient algorithms for computing with genomic intervals will be examined in detail. Statistical methods for testing gene-centric or pathway-centric hypotheses with genome-scale data are found in packages such as limma, some of these techniques will be illustrated in lectures and labs.

Given the diversity in educational background of our students we have divided the series into seven parts. You can take the entire series or individual courses that interest you. If you are a statistician you should consider skipping the first two or three courses, similarly, if you are biologists you should consider skipping some of the introductory biology lectures. Note that the statistics and programming aspects of the class ramp up in difficulty relatively quickly across the first three courses. By the third course will be teaching advanced statistical concepts such as hierarchical models and by the fourth advanced software engineering skills, such as parallel computing and reproducible research concepts.

These courses make up two Professional Certificates and are self-paced:

Data Analysis for Life Sciences:

Genomics Data Analysis:

This class was supported in part by NIH grant R25GM114818.

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De un vistazo

  • Idioma: English
  • Transcripción de video: English
  • Habilidades asociadas:Microarrays, Data Warehousing, Functional Genomics, Bioconductor (Bioinformatics Software), Life Sciences, Matrix Algebra, Algorithms, Data Analysis, Statistical Inference, R (Programming Language), Statistical Methods, Biology, Linear Model, DNA Sequencing, Statistics, Next-Generation Sequencing, Software Engineering

Lo que aprenderás

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  • What we measure with high-throughput technologies and why
  • Introduction to high-throughput technologies
    • Next Generation Sequencing
    • Microarrays
  • Preprocessing and Normalization
  • The Bioconductor Genomic Ranges Utilities
  • Genomic Annotation

Este curso es parte del programa Data Analysis for Genomics Professional Certificate

Más información 
Instrucción por expertos
3 cursos de capacitación
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3 meses
2 - 4 horas semanales

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