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Behavioral Neuroscience: Analyzing Anxiety and Depression

Learn how to collect scientific data using behavioral tests that measure anxiety and depression in laboratory mice, and interpret and discuss the results in the context of anxiety and depression in humans and a mouse model of obsessive-compulsive disorder.

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Behavioral Neuroscience: Analyzing Anxiety and Depression

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Behavioral Neuroscience: Analyzing Anxiety and Depression

Learn how to collect scientific data using behavioral tests that measure anxiety and depression in laboratory mice, and interpret and discuss the results in the context of anxiety and depression in humans and a mouse model of obsessive-compulsive disorder.

Behavioral Neuroscience: Analyzing Anxiety and Depression
Aproximadamente 5 semanas
5–7 horas por semana
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Hay una sesión disponible:

Una vez finalizada la sesión del curso, será archivadoAbre en una pestaña nueva.
Comienza el 30 ago

Sobre este curso

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  • Obtain competency in using behavioral tests to measure anxiety and depression in laboratory mice.
  • Collect behavioral data from mouse videos from compulsive-like, non-compulsive-like, and randomly bred mouse strains; a mouse model of obsessive-compulsive disorder (OCD).
  • Establish a foundation in using behavioral tests in laboratory mice to be able to confidently learn how to use new tests.
  • Develop an ability to analyze behavioral data.
  • Develop an ability to interpret and discuss results in the context of human psychiatric disorders and the mouse model of OCD.
  • Obtain a competency in describing key characteristics of anxiety and depression in humans and in animal models.
  • Develop an ability to compare and contrast compulsive-like, anxiety-like, and depression-like behaviors in mice to equivalent conditions in humans.
  • Develop a capability to formulate original research hypotheses.
  • Obtain a competency in describing and discussing how basic research, as performed in this certificate program, contributes to the animal model of OCD and how it may have the potential to contribute to improving the human condition.
  • Learners who join this course should be free of objections to using mice in research.

De un vistazo

  • Institución: AlaskaX
  • Tema: Biología y ciencias humanas
  • Nivel: Intermediate
  • Prerrequisitos:

    Completion of NEURO1x: Behavioral Neuroscience: Foundations of Compulsive Behaviors and accompanying Institutional Animal Care and Use Committee (IACUC) training

Lo que aprenderás

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  • Compare and contrast human and mouse behaviors.
  • Collect, analyze, and interpret behavioral data from mouse videos.
  • Establish a foundation in using behavioral tests in laboratory mice.
  • Understand anxiety and depression in humans and in animals.
  • Understand the role of animal models in studying human psychiatry.

Plan de estudios

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  • Module 1: Introduction, Anxiety: Background - open field test
  • Module 2: Anxiety: Data Collection and Analysis
  • Module 3: Depression: Background - tail suspension test
  • Module 4: Depression: Data Collection and Analysis
  • Module 5: Interpretation of results

Acerca de los instructores

Preguntas frecuentes

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Q: Are new mice used for this course?

A: No. All the mice were used in other courses and experiments prior to including them in this course.

Q: Do any mice suffer while participating in the behavioral test?

A: No. Some of the behavioral tests may have been stressful, such as the forced swim test or the tail suspension test. However, the stress was equivalent to what a mouse might experience while living in the animal facility, such as reestablishing a dominance hierarchy in a new and clean home cage.

Q: Are the mice killed at the end of the behavioral tests?

A: Yes. The mice were euthanized following federally required euthanasia procedures that minimize pain and distress. Most mice were used for several tests in order to reduce the total number of mice used.

Q: What happens if a mouse gets sick?

A: If a mouse got sick, it was checked by animal care and/or veterinary staff. If the illness was minor and treatable, it received appropriate care and was returned to its home cage. If the illness was severe, the mouse was euthanized following federally required euthanasia procedures that minimize pain and distress. Subsequently, the animal was necropsied to identify the cause of death. Causes of death usually included a tumor, kidney failure, a genetic anomaly, or an infection. Very few mice became ill.

Q: What happens if a mouse dies?

A: If a mouse died, it was necropsied to identify the cause of death. Causes of death usually included a tumor, kidney failure, a genetic anomaly, or an infection. Very few mice died.

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