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Stacy L. Springs

Executive Director, Center for Biomedical Innovation at Massachusetts Institute of Technology

Areas of expertise

  • - Organic & Biophysical Chemistry
  • - Biomanufacturing
  • - Food Safety
  • - Regulatory Science

Major works

  • Destro, F., et al., Springs S.L., et al. Mechanistic modeling explains the production dynamics of recombinant adeno-associated virus with the baculovirus expression vector system. Molecular Therapy-Methods & Clinical Development 2023 https://doi.org/10.1016/j.omtm.2023.05.019
  • Barone, P.W., et al., Springs S.L. Historical evaluation of the in vivo adventitious virus test and its potential for replacement with next generation sequencing (NGS). Biologicals; 2022. 10.1016/j.biologicals.2022.11.003
  • Strutt, J.P.B, et al., Springs, S.L., 2022. Machine-learning based detection of adventitious microbes in T-cell therapy cultures using long read sequencing BioRxiv https://doi.org/10.1101/2022.11.03.514634

Social links

About me

Dr. Stacy Springs is Executive Director of MIT’s Center for Biomedical Innovation (CBI). The Center integrates the Institute’s technical, scientific, and management expertise to solve complex biopharmaceutical challenges. CBI leads multi-stakeholder, multidisciplinary research and educational initiatives with real world impact, including MIT's Biomanufacturing Consortium (BioMAN) and it's Consortium on Adventitious Agent Contamination in Biomanufacturing (CAACB). Dr. Springs is the principal investigator on several research programs in biologics manufacturing, from application of data analytics and PAT in the continuous production of monoclonal antibodies, viral vectors and vaccines; to development of innovative rapid sterility tests and new approaches to adventitious agent contamination through long read sequencing. Dr. Springs is part of the leadership of SMART CAMP, an interdisciplinary research group focused on Critical Analytics for Manufacturing Personalized-Medicine at the Singapore-MIT Alliance for Research and Technology (SMART) and serves as the Chair of Landmark Bio’s Science and Technology Committee.

In addition, Dr. Springs serves as the Executive Director for the MIT Sloan’s Food Supply Chain Analytics and Sensing Initiative, (FSAS).

She holds a PhD in Chemistry from the University of Texas at Austin and gained postdoctoral training in protein and biophysical chemistry at Princeton University.