This series of courses begins with an introduction to the US healthcare delivery system, its many systemic challenges and the prior efforts to develop and deploy informatics tools to help overcome those problems. It goes on to discuss health informatics from an historical perspective, its current state and its likely future state now that electronic health record systems are widely deployed, the HL7 FHIR (Fast Healthcare Interoperability Resources) standard is being rapidly accepted as the means to access and share the data stored in those systems and analytics is increasing being used to support clinical research using that aggregated data. It then turns to the impact of FHIR in transforming healthcare with a focus on some of the important and evolving areas of informatics including health information exchange, population health, public health, mHealth and big data and analytics. Use cases and case studies are used in all of these discussions to help students connect the technologies to real world challenges.