Michael Birnbaum

Prof. Birnbaum obtained an A.B. in Chemical and Physical Biology at Harvard University in 2008. He then moved to Stanford University, where he completed his Ph.D. in Immunology in 2014. At Stanford, he worked in Professor K. Christopher Garcia’s laboratory, studying the molecular mechanisms of T cell receptor recognition, cross-reactivity, and activation. He then conducted postdoctoral research in Professor Carla Shatz’s laboratory, studying novel roles for immune receptors expressed by neurons in neural development and neurodegenerative disease. Michael joined the Department of Biological Engineering in 2016 as an Assistant Professor.

Prof. Birnbaum’s lab focuses on understanding and manipulating ‘natural’ adaptive immune responses in the context of cancer and infection. We use a variety of strategies and techniques including protein biochemistry, protein engineering, sequencing, and bioinformatics to 1) identify immune cells of interest, 2) determine the sequences of their antigen receptors, 3) directly determine what the immune response is ‘seeing’ in response to cancer or infection, and 4) answer questions about how the immune system composition and dynamics affect the success or failure of an immune response. This type of systematic, unbiased examination of the antigen recognition repertoire of any given T or NK cell receptor has, until recently, been extremely difficult. With this information, we will be able to rationally engineer new methods to more specifically and potently mount a potent immune response.