Drug Discovery & Medicinal Chemistry

Learn how scientists in drug development modify and test molecules to improve potency and reduce toxicity. Discover the criteria that regulatory agencies use to approve molecules that are shown to be both safe and effective as pharmaceuticals for the treatment and prevention of diseases.

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Students planning to complete the course should have the prerequisites listed below.

high school algebra - logarithmic and exponential functions
high school biology - general anatomy and basic cell structure
high school general chemistry - equilibrium and intermolecular forces
introductory organic chemistry - functional group recognition and line-angle structures

Students who do not have these prerequisites will understand much of the course content but may have difficulty earning a passing grade.

Sobre este curso

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Drug discovery is a challenging field, but the pathway most drugs navigate from concept to market is predictable and based upon repeated experimentation. The process requires scientists with expertise in chemistry, biology, and medicine. This course focuses on four aspects of drug development.

regulation - approval protocols for government regulatory agencies
pharmacodynamics - how a drug affects the body
pharmacokinetics - how a drug flows through the body
lead discovery/optimization - the steps for finding and improving molecules as potential drugs

The course closes with two case studies of molecules that have advanced through the development process and into clinical trials.

Lo que aprenderás

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After completing this course, students will be able to...

contrast the different steps of the drug discovery process,
summarize the relationship between patents and generic drugs,
interpret dose-response curves from the action of drugs on proteins,
calculate drug-target binding energies from potency measures,
describe factors that affect the flow of a drug through the body,
predict structural changes in a molecule to influence half-life,
priorize weakly active molecules as potential drug candidates,
implement modifications to improve the properties of drug-like molecules, and
assess literature reports of drug development programs.

Plan de estudios

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Module 0 - Welcome
Module 1 - Drug Discovery Process
Module 2 - Drug Targets
Module 3 - Drug Metabolism & Pharmacokinetics
Module 4 - Lead Discovery & Optimization
Module 5 - Case Studies from the Literature
Module 6 - Farewell

Conoce a tus instructores

Davidson College

Erland Stevens

Faculty, Chemistry

Davidson College

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Prerrequisitos

Sobre este curso

Lo que aprenderás

Plan de estudios

Conoce a tus instructores

Obtén un Certificado Verificado para destacar los conocimientos y las habilidades que adquieras$99 USD

Oficial y verificado

Fácil de compartir

Incentivo comprobado

Apoya nuestra labor

Obtén un Certificado Verificado para destacar los conocimientos y las habilidades que adquieras
$99 USD