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Behavioral Neuroscience: Contrasting Tests for Anxiety and Depression

Learn how to critically evaluate the use of different behavioral tests for anxiety and depression in laboratory mice, and how these tests can affect the interpretation of results in the context of human psychiatric conditions and mouse models.

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Behavioral Neuroscience: Contrasting Tests for Anxiety and Depression

There is one session available:

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After a course session ends, it will be archivedOpens in a new tab.
Starts Sep 27

Behavioral Neuroscience: Contrasting Tests for Anxiety and Depression

Learn how to critically evaluate the use of different behavioral tests for anxiety and depression in laboratory mice, and how these tests can affect the interpretation of results in the context of human psychiatric conditions and mouse models.

Behavioral Neuroscience: Contrasting Tests for Anxiety and Depression
Estimated 5 weeks
5–7 hours per week
Self-paced
Progress at your own speed
Free
Optional upgrade available

There is one session available:

After a course session ends, it will be archivedOpens in a new tab.
Starts Sep 27

About this course

Skip About this course
  • Learn how to critically evaluate the use of different behavioral tests for anxiety and depression in laboratory mice.
  • Evaluate how different behavioral tests can affect the interpretation of results.
  • Collect behavioral data from mouse videos from compulsive-like, non-compulsive-like, and randomly bred mouse strains; a mouse model of obsessive-compulsive disorder (OCD).
  • Develop an ability to analyze behavioral data.
  • Develop an ability to interpret and discuss results in the context of human psychiatric disorders and the mouse model of OCD.
  • Obtain a competency in describing key characteristics of anxiety and depression in humans and in animal models.
  • Develop an ability to compare and contrast compulsive-like, anxiety-like, and depression-like behaviors in mice to equivalent conditions in humans.
  • Develop a capability to formulate original research hypotheses.
  • Obtain a competency in describing and discussing how basic research, as performed in this certificate program, contributes to the animal model of OCD and how it may have the potential to contribute to improving the human condition.
  • Learners who join this course should be free of objections to using mice in research.

At a glance

  • Institution: AlaskaX
  • Subject: Biology & Life Sciences
  • Level: Intermediate
  • Prerequisites:

    Completion of NEURO1x: Behavioral Neuroscience: Foundations of Compulsive Behaviors and accompanying Institutional Animal Care and Use Committee (IACUC) training

What you'll learn

Skip What you'll learn
  • Critically evaluate the use of different behavioral tests in mice.
  • Collect, analyze, and interpret behavioral data from mouse videos.
  • Establish a foundation in using behavioral tests in laboratory mice.
  • Develop ability to compare and contrast different behaviors in mice.
  • Understand the role of animal models in studying human psychiatry.
  • Module 1: Introduction, Anxiety: Background - elevated zero maze test
  • Module 2: Anxiety: Data Collection and Analysis
  • Module 3: Depression: Background - forced swim test
  • Module 4: Depression: Data Collection and Analysis
  • Module 5: Interpretation of results

About the instructors

Frequently Asked Questions

Skip Frequently Asked Questions

Q: Are new mice used for this course?

A: No. All the mice were used in other courses and experiments prior to including them in this course.

Q: Do any mice suffer while participating in the behavioral test?

A: No. Some of the behavioral tests may have been stressful, such as the forced swim test or the tail suspension test. However, the stress was equivalent to what a mouse might experience while living in the animal facility, such as reestablishing a dominance hierarchy in a new and clean home cage.

Q: Are the mice killed at the end of the behavioral tests?

A: Yes. The mice were euthanized following federally required euthanasia procedures that minimize pain and distress. Most mice were used for several tests in order to reduce the total number of mice used.

Q: What happens if a mouse gets sick?

A: If a mouse got sick, it was checked by animal care and/or veterinary staff. If the illness was minor and treatable, it received appropriate care and was returned to its home cage. If the illness was severe, the mouse was euthanized following federally required euthanasia procedures that minimize pain and distress. Subsequently, the animal was necropsied to identify the cause of death. Causes of death usually included a tumor, kidney failure, a genetic anomaly, or an infection. Very few mice became ill.

Q: What happens if a mouse dies?

A: If a mouse died, it was necropsied to identify the cause of death. Causes of death usually included a tumor, kidney failure, a genetic anomaly, or an infection. Very few mice died.

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