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HarvardX: Statistical Inference and Modeling for High-throughput Experiments

A focus on the techniques commonly used to perform statistical inference on high throughput data.

4 weeks
2–4 hours per week
Self-paced
Progress at your own speed
Free
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Statistical Inference and Modeling for High-throughput Experiments

About this course

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In this course you’ll learn various statistics topics including multiple testing problem, error rates, error rate controlling procedures, false discovery rates, q-values and exploratory data analysis. We then introduce statistical modeling and how it is applied to high-throughput data. In particular, we will discuss parametric distributions, including binomial, exponential, and gamma, and describe maximum likelihood estimation. We provide several examples of how these concepts are applied in next generation sequencing and microarray data. Finally, we will discuss hierarchical models and empirical bayes along with some examples of how these are used in practice. We provide R programming examples in a way that will help make the connection between concepts and implementation.

Given the diversity in educational background of our students we have divided the series into seven parts. You can take the entire series or individual courses that interest you. If you are a statistician you should consider skipping the first two or three courses, similarly, if you are biologists you should consider skipping some of the introductory biology lectures. Note that the statistics and programming aspects of the class ramp up in difficulty relatively quickly across the first three courses. By the third course will be teaching advanced statistical concepts such as hierarchical models and by the fourth advanced software engineering skills, such as parallel computing and reproducible research concepts.

These courses make up two Professional Certificates and are self-paced:

Data Analysis for Life Sciences:

Genomics Data Analysis:

This class was supported in part by NIH grant R25GM114818.

At a glance

  • Language: English
  • Video Transcript: English
  • Associated skills: Next-Generation Sequencing, Data Warehousing, Linear Model, Bayesian Statistics, Exploratory Data Analysis, Functional Genomics, Maximum Likelihood, Statistics, Bioconductor (Bioinformatics Software), Life Sciences, Matrix Algebra, Research, Data Analysis, Biology, Statistical Inference, Software Engineering, DNA Sequencing, Statistical Modeling, R (Programming Language)

What you'll learn

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  • Organizing high throughput data
  • Multiple comparison problem
  • Family Wide Error Rates
  • False Discovery Rate
  • Error Rate Control procedures
  • Bonferroni Correction
  • q-values
  • Statistical Modeling
  • Hierarchical Models and the basics of Bayesian Statistics
  • Exploratory Data Analysis for High throughput data

More about this course

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HarvardX requires individuals who enroll in its courses on edX to abide by the terms of the edX honor code. HarvardX will take appropriate corrective action in response to violations of the edX honor code, which may include dismissal from the HarvardX course; revocation of any certificates received for the HarvardX course; or other remedies as circumstances warrant. No refunds will be issued in the case of corrective action for such violations. Enrollees who are taking HarvardX courses as part of another program will also be governed by the academic policies of those programs.

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Harvard University and HarvardX are committed to maintaining a safe and healthy educational and work environment in which no member of the community is excluded from participation in, denied the benefits of, or subjected to discrimination or harassment in our program. All members of the HarvardX community are expected to abide by Harvard policies on nondiscrimination, including sexual harassment, and the edX Terms of Service. If you have any questions or concerns, please contact harvardx@harvard.edu and/or report your experience through the edX contact form.

HarvardX Research Statement
HarvardX pursues the science of learning. By registering as an online learner in an HX course, you will also participate in research about learning. Read our research statement to learn more.

This course is part of Data Analysis for Life Sciences Professional Certificate Program

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Expert instruction
4 skill-building courses
Self-paced
Progress at your own speed
4 months
2 - 4 hours per week

Ways to take this course

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Price

$219 USD

Free

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Limited

Expires on Dec 29

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Shareable certificate upon completion

Graded assignments and exams

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